July 29, 2025

Nonblistering Papules: Genetic Mystery Cracked

A woman with a decades-long history of intensely pruritic, nonblistering papules on her extremities was diagnosed with dystrophic epidermolysis bullosa pruriginosa, confirmed by COL7A1 gene sequencing, after a comprehensive clinicopathologic evaluation.

Conexiant

July 28, 2025

Planned Cesarean May Raise B-Cell ALL Risk in Children

A Swedish cohort study of over 2.4 million births found that children born via planned cesarean section had a higher risk of developing B-cell precursor acute lymphoblastic leukemia before age 6, independent of maternal or perinatal factors.

Conexiant

July 24, 2025

Tooth Loss, Gum Disease Linked to Stomach Cancer

Using sibling comparisons and nationwide registries, researchers evaluate how inflammation and tooth count independently affect gastric cancer risk in adults across Sweden.

Conexiant

July 23, 2025

HER2DX Assay and Survival Outcomes in HER2-Positive Breast Cancer

In an individual patient-level meta-analysis reported in The Lancet Oncology, Villacampa et al found that the HER2DX assay risk score was prognostic for event-free survival outcomes in patients with e...

The ASCO Post

July 23, 2025

6 Blood Proteins Predict Kidney Function Decline

A 6-protein blood-based model predicted kidney function decline in patients with ADPKD more accurately than clinical or imaging-based models, and offers a new pathway for outcome prediction.

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July 22, 2025

Placenta Accreta Guidelines Lack Consensus: Review

A new review of clinical guidelines highlights consistent recommendations for diagnosing and managing placenta accreta spectrum disorders, but showed gaps in guidance for surgery, fertility counseling, and postnatal care, especially in low-resource settings.

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July 22, 2025

Might That Lip Lesion Be BCC?

New research has documented 4 cases of lip basal cell carcinoma presenting as smooth yellow nodules—a rare clinical presentation that may be mistaken for benign mesenchymal tumors, potentially resulting in diagnostic delays and postponed treatment.

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July 22, 2025

DNA Methylation Links Mucinous Cystic Neoplasms to Ovarian Neoplasms

Genome-wide DNA methylation analysis shows that pancreatic and liver mucinous cystic neoplasms share epigenetic profiles with mucinous ovarian tumors

The Pathologist

July 21, 2025

Melanoma Risk Differs by Mole Count and Genetic Profile

A large study found distinct genetic and phenotypic risk patterns for nevus-associated and de novo invasive melanomas.

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