Harold Burstein, MD, PhD; Sara Tolaney, MD, MPH; Nancy Lin, MD; Sarah Sammons, MD; Ana C. Garrido-Castro, MD; and Elizabeth Ann Mittendorf, MD, PhD, MHCM, discuss important breast cancer research presented at the 2025 San Antonio Breast Cancer Symposium, including maintenance strategies for HER2+ metastatic breast cancer, SERDs in early and late stage breast cancer, antibody-drug conjugates in ER+ metastatic breast cancer, local therapy and screening, and how ctDNA drives clinical studies.