April 29, 2025

Richard Pazdur, MD, Honored With 2025 AACR Enduring Impact Award for Transformative Service to Cancer Science and Medicine

During the 2025 American Association for Cancer Research (AACR) Annual Meeting, Richard Pazdur, MD, accepted an award and gave remarks during the meeting’s Opening Ceremony.

The ASCO Post

April 29, 2025

AACR 2025: Oral HER2-Targeted Therapy for Advanced HER2-Mutated Lung Cancer

The novel HER2-targeted tyrosine kinase inhibitor zongertinib elicited durable responses in patients with advanced, previously treated non–small cell lung cancer (NSCLC) that harbored a HER2 mutation,...

The ASCO Post

April 29, 2025

AACR 2025: Novel Targeted Therapy Under Study in Selected Patients With Advanced Solid Tumors

According to the results of a phase I trial, the first-in-class covalent Werner helicase inhibitor (RO7589831) demonstrated early signals of efficacy as well as general tolerability in patients with a...

The ASCO Post

April 29, 2025

AACR 2025: AI-Driven Model For Identifying Cancer Cachexia

Use of a multimodal deep learning–based model led to more accurate and earlier identifications of cancer cachexia than standard clinical and radiological observations, according to findings presented ...

The ASCO Post

April 28, 2025

AACR 2025: Nonoperative Management of Mismatch Repair–Deficient Tumors

PD-1 blockade with the PD-1 inhibitor dostarlimab-gxly induced complete tumor clearance and resolved the need for surgery in patients with locally advanced, mismatch repair–deficient cancers, accordin...

The ASCO Post

April 28, 2025

AACR 2025: Use of ctDNA-Based Liquid Biopsy Assay in Resectable Colorectal Cancer

Interim results from the VICTORI study, which were presented at the 2025 American Association for Cancer Research (AACR) Annual Meeting, showed that an ultrasensitive circulating tumor DNA (ctDNA)-bas...

The ASCO Post

April 25, 2025

Omission of Endocrine Therapy in Estrogen Receptor–Low, Early-Stage Breast Cancer

In a study reported in the Journal of Clinical Oncology, Choong et al looked at whether the omission of endocrine therapy in patients with estrogen receptor–low (1%–10% on immunohistochemistry), early...

The ASCO Post

April 25, 2025

Childhood Exposure to Bacterial Toxin May Trigger Early-Onset Colorectal Cancer

Researchers may have identified a bacterial toxin as a potential factor contributing to the concerning rise in early-onset colorectal cancer.

The ASCO Post

April 25, 2025

WHI Funding Future Unclear

Women’s Health Initiative (WHI) investigators were informed on April 21 that the Department of Health and Human Services (HHS) will terminate WHI Regional Center contracts at the end of the current fi...

The ASCO Post