Pediatric tibial tubercle fractures continue to present diagnostic and treatment challenges as clinicians navigate variable imaging use, classification systems, and surgical thresholds in the absence of standardized guidelines.
Cluster 2 patients exhibited ‘a more severe form of the disease, marked with frequent serositis and haematological manifestations, renal and neurological involvement,’ and had poorer outcomes over time.
A large genetic study in U.S. veterans has identified ENPP1 and RNF144B as genes associated with calcium pyrophosphate deposition disease, suggesting potential for targeted treatment approaches.
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"As the calcaneus grows in size, it becomes taller, wider, and relatively shorter—essentially, more cube-like—revealing nature’s quiet strategy to manage internal bone stress."
A humanized monoclonal antibody that targets CD19+ B cells is first FDA-approved treatment for immunoglobulin G4–related disease, reducing flare risk and glucocorticoid use in clinical trials.