July 25, 2025

Tofacitinib Curbs Inflammation, Not Thrombosis Risk

Tofacitinib dampens inflammatory cytokine production in rheumatoid arthritis models but fails to counteract endothelial prothrombotic responses, highlighting ongoing cardiovascular safety concerns.

Conexiant

July 25, 2025

Rare Pediatric Knee Fractures Reviewed in Depth

Pediatric tibial tubercle fractures continue to present diagnostic and treatment challenges as clinicians navigate variable imaging use, classification systems, and surgical thresholds in the absence of standardized guidelines.

Conexiant

July 21, 2025

Coping Trumps Pleasure in Predicting Comfort Eating

Researchers explore how psychological expectations—such as boredom relief and mood regulation—drive the frequency of comfort food consumption in adults.

Conexiant

July 15, 2025

Genetic Markers Don’t Guide RA Drug Choice

A large UK study found no significant difference in treatment effectiveness between abatacept and adalimumab for rheumatoid arthritis, regardless of patients’ HLA-DRB1 genetic profiles.

Conexiant

July 15, 2025

Fibrinogen Concentrate Reduces Blood Loss in Surgery

In a phase 3 trial, a purified human fibrinogen concentrate reduced intraoperative blood loss and lowered thromboembolic risks compared with fresh frozen plasma or cryoprecipitate during major surgeries.

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July 15, 2025

Methotrexate Shows No Knee OA Symptom Benefit, Study Finds

A 52-week randomized clinical trial found no significant difference between methotrexate and placebo in reducing pain or effusion-synovitis in patients with inflammatory knee osteoarthritis.

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July 10, 2025

Tramadol Carries Lowest Constipation Risk Among Opioids

The UK hospital study of over 80,000 patients found that certain opioids, including morphine and oxycodone, carried a higher risk of severe constipation compared with others.

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July 09, 2025

Four Diagnostic Paths Found to Predict Alzheimer’s

A study of over 24,000 patients identified four common diagnostic paths that lead to Alzheimer’s disease, with multi-step sequences posing higher risk than single conditions and showing reproducibility in a national validation cohort.

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July 08, 2025

Mediterranean Diet’s 30-Year Legacy

A sweeping 30-year review confirms the Mediterranean-style diet lowers risks of heart disease, diabetes, cancer, and cognitive decline—while supporting global sustainability.

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