May 01, 2025

Fas Inhibition Shows Neuroprotective Benefit for GA

An investigational Fas inhibitor demonstrated encouraging results in patients with geographic atrophy (GA) in a phase 1b clinical trial. In the study, eyes treated with ONL1204 (ONL Therapeutics) showed reductions in GA lesion growth at 6 months of up to 50% compared to sham-treated eyes after 2 injections spaced 3 months apart, and a 42% reduction in lesion growth compared to fellow untreated eyes after a single injection.

Retinal Physician

May 01, 2025

Who Stops GA Therapy—and Why

A large, retrospective analysis of more than 20,000 eyes treated for geographic atrophy (GA) suggests that several baseline clinical characteristics—including coexisting neovascular age-related macular degeneration (nAMD) and poor initial visual acuity—are significantly associated with early discontinuation of intravitreal complement inhibitor therapy.

Retinal Physician

July 14, 2025

Video: Can Vonaprument Slow Vision Loss in GA?

David Eichenbaum, MD, and Diana Do, MD, discuss the rationale for and progress of the fully enrolled ARCHER II trial at ASRS 2025.

Retinal Physician

July 14, 2025

Video: Dual-Action Gene Therapy for DME Shows Safety and Durability

David Almeida, MD, presented interim data from the SPECTRA trial of 4D-150 gene therapy in adults with diabetic macular edema

Retinal Physician

April 01, 2025

AI Scribing and Telephone Management

In his ASCRS 2025 presentation titled "AI Scribing and Telephone Management," Robert T. Chang, MD, shared his insights about how artificial intelligence has impacted his practice and how it can help other practices to be more efficient.

Ophthalmology Management

May 08, 2025

Aldeyra Therapeutics Achieves Primary Endpoint in Phase 3 DED Chamber Trial of Reproxalap

In a dry eye chamber trial, Reproxalap was statistically superior (P = .002) to vehicle in primary endpoint of ocular discomfort.

Ophthalmology Management

January 01, 2024

LIVESTREAM Q + A

PentaVision is an independent company dedicated to eye care professionals. More about our magazines, newsletters, conferences, education and other services at pentavisionmedia.com.

Contact Lens Spectrum

April 01, 2025

Why Cataract Payments Keep Falling

Medicare’s reimbursement formula leaves ophthalmic surgeons with shrinking compensation. To reverse this trend, advocacy is critical.

Ophthalmology Management

April 26, 2025

Cataract Surgery in Patients With Corneal Disease

Zeba A. Syed, MD, shares what physicians need to know when treating patients for cataracts.

Ophthalmology Management