In a randomized trial of more than 2,500 patients at high cardiovascular risk, obicetrapib significantly reduced low-density lipoprotein cholesterol levels when added to existing lipid-lowering therapy.
A randomized trial of 160 adults with depression and obesity found no improvement in mood symptoms from adding simvastatin to escitalopram, though the statin significantly lowered cholesterol and inflammation levels.
In a large study across 8 countries, researchers found that ultraprocessed food consumption contributed to thousands of premature deaths annually, with higher risks in countries where these foods dominate diets.
A Phase I study of intrathecal resiniferatoxin in patients with advanced cancer pain shows promising reductions in pain and opioid use, with durable effects and manageable side effects.
A new clinical trial is investigating whether removing clots using a modified access point can better prevent post-thrombotic syndrome in patients with extensive deep vein thrombosis.
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A large population study found that higher dietary fiber intake was associated with reduced risk of stroke and improved survival among stroke survivors, with genetic evidence supporting a causal link for small vessel stroke.
A large research review found that depression diagnosed in either midlife or late life was linked to a significantly higher risk of developing dementia.
A large population study found that individuals with Down syndrome face a significantly higher risk of stroke, particularly at younger ages, while their risk of heart attack is generally similar to the general population but elevated before age 40.