As patients age and treatment courses evolve, ongoing medication reassessment becomes critical to minimizing risk and optimizing safety. In this practical session, Dr. Jessica Gurley reviews indications for deprescribing psychiatric medications, high-risk medication classes, common barriers, and structured tapering strategies—including the A-TAPER model. Emphasis is placed on risk–benefit evaluation, patient engagement, and individualized taper plans to reduce adverse outcomes while maintaining clinical stability.