In a randomized clinical trial of patients at increased risk for persistent symptoms, clinician-supported biopsychosocial self-management was associated with lower pain impact and fewer chronic pain outcomes than guideline-based medical care.
Two hours of daily screen use in the first 3 days following a concussion was associated with faster symptom resolution — but the observational design limits conclusions about cause and effect.
Nearly 40% of registry patients would have been excluded from phase 3 randomized controlled trials, with exclusion criteria distributed unevenly across drug classes.
Researchers urge caution in interpreting joint replacement predictors, noting that surgery reflects access and decision-making as well as disease biology.
Teriparatide followed by zoledronic acid increased bone mineral density but did not reduce fracture risk compared with standard care in adults with osteogenesis imperfecta.
In a UK cohort, patients with osteoarthritis who initiated centrally acting analgesics had a higher hazard of knee or hip replacement than those who initiated SSRIs, though residual confounding by pain severity remains a key limitation.
Swedish registry analysis linked surgical treatment with better patient-reported function in comminuted intra-articular distal radius fractures, while other fracture patterns showed limited benefit.